Moundville is a town in Hale and Tuscaloosa counties in the U.S. state of Alabama. It incorporated on December 22, 1908. From its incorporation until the 1970 census, it was wholly within Hale County. At the 2010 census the population was 2,427, up from 1,809 at the 2000 census. It is part of the Tuscaloosa Metropolitan Statistical Area. Within the town is Moundville Archaeological Site, the location of a prehistoric Mississippian culture political and ceremonial center.